Significantly no, but it will generate more heat which will wear all parts of the DSG more quickly but nothing to worry about. The DSG is designed and intended to last 100k miles or more and with a remap, depending on who made it I guess, you could be in trouble around 80k miles or more. Its also very complicated as in 1 in 1 million DSG's standard may fail below 100k miles and with a remap now 2 in 1 million may fail (not exact numbers but you get the idea of how it works). The other 999,998 may be just fine.
....I would have expected a German car manufacturer to have designed it to last a lot longer than 100k miles.
The DSG remap on my K03 car seems very subtle and so it's not easy to understand how a significant amount of extra heat is generated and how it would be detrimental.
Its the sliding scale and number of failures. Most OEM's follow Six Sigma with every part they make or source or design. However, their primary concern is the warranty period so when the bean counters get involved in reducing costs, Six Sigma may be thrown out the window. From the engineers I know inside the VW Group, engines and components are designed to 150k miles and transmissions and components are designed to 100k miles considering a mixed use by the consumer. Testing procedures are secret and vary but all try to recreate how the average customer will use the car. Porsche goes a little bit further and so do Audi S and RS models where their testing procedures incorporate more spirited use of the vehicles.
All OEMs have an internal policy on the accepted number of failures at x number of miles or hours. Its all relative however to many variables. If you exceed torque ratings, etc. and drive it hard, often, your risk of failure greatly increases. If you exceed torque ratings but never use the torque, it may not fail any more quickly than a standard.
Remapping changes the shift points and the speed at which the clutches engage. Both of these increase the gear box temperatures. So do increases in torque. Shifting at 7200 rpm's instead of 6850 rpm's is going to generate more heat, no way around that. Slipping the clutches faster with a quicker engagement is going to generate more heat as well, no way around that.
For example, let's say VW/Borg Warner designed the DSG transmission to last 100k miles at an average gear box temp of 40 deg c. Remapping it may result in average temps of say 45 deg c depending on how you drive. The extra 5 deg c will reduce the life. How much? Don't know, nobody other than perhaps the OEM has tested it.