Hi
When stationary, I can alter all sorts of settings - brightness of interior lights, welcome/coming home lights-on delay, central locking driver's door only, etc etc. Many of these are otherwise only accessible through VCDS. I suspect you need the highline display to get full benefit.
On the move, you obviously get control of your ICE and this will depend on what you've got fitted. With original VW equipment, you'll have control over mode, volume, track, station etc. You can also scroll through the trip computer functions (set 1 and 2), as stated in the post above.
I find the MFSW a real boon, especially with a DSG 'box. You can keep your hands at quarter to three while muting or changing tracks. I miss it when I have to reach for the little volume button on my wife's Passat. (Separate rant - why can't they move the volume button across to the right hand side for those of us who drive on the correct side of the road?)